pluriBead® uses non-magnetic monodispersed microparticles (beads) for the sorting of cell mixtures. The beads are larger than the cells and thus cannot be phagocytized by them. Their surface is modified with monoclonal antibodies that recognize specific structures on the target cell surface. During incubation, the target cells in suspension will bind to the pluriBeads® and can be separated afterwards by a pluriStrainer® (size exclusion) from the suspension. Pretreatment of the blood, such as the production of a mononuclear cell fraction (PBMC) or others (e.g. erythrolysis or target concentration), is not required.